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Pharmacokinetics of tiagabine as add-on therapy in patients taking enzyme-inducing antiepilepsy drugs

✍ Scribed by Elson L. So; Denise Wolff; Nina M. Graves; Ilo E. Leppik; Gregory D. Cascino; Glenn C. Pixton; Linda E. Gustavson

Book ID
108022888
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
406 KB
Volume
22
Category
Article
ISSN
0920-1211

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The authors set out to determine the effect of intrapatient dose escalation of irinotecan on its disposition in pediatric patients with high-grade glioma who received concomitant enzyme-inducing anticonvulsants (EIAs). During Course 1, a 60-minute intravenous infusion of irinotecan (20 mg/m(2) per d