The evaluation of drugs in vivo is often based on experimental models using small animals such as mice, rats and rabbits. However, these models could be improved to correspond more closely to the human situation if the pharmacokinetics of the drugs tested in animals were similar to that observed in
Pharmacokinetics of three sulfonamides in the rabbit
โ Scribed by Kerry Ann McMahon; W. J. O'Reilly
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 623 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^โ1^) during a continuous MTX infusion (1ยท2 mg kg^โ1^) over 240 min. IND was injected i.v. at hourly intervals after a steady