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Pharmacokinetics of the phosphatidylserine tracers99mTc-lactadherin and99mTc-annexin V in pigs

✍ Scribed by Runa H Poulsen, Jan T Rasmussen, June Anita Ejlersen, Christian Flø…

Book ID
120730499
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
242 KB
Volume
3
Category
Article
ISSN
2191-219X

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Improvement in radiolabelling proteins with the 99mTc-tricarbonyl-core [99mTc(CO)3]+, by thiol-derivatization with iminothiolane: application to γ-globulins and annexin V
✍ Marie-Laure Biechlin; Amaury du Moulinet d'Hardemare; Marc Fraysse; François-Noë 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 143 KB

The aim of this study was to improve the radiolabelling of proteins with the 99m Tctricarbonyl-[Tc(I)(CO) 3 ] + core by introducing thiol groups to their structure. To achieve this goal, g-globulins and annexin V were derivatized with mercaptobutyrimidyl groups (MBG) after reaction with 2-iminothiol