Pharmacokinetics of the enantiomers of ibuprofen in the rabbit
✍ Scribed by K. M. Williams; R. D. Knihinicki; R. O. Day
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1991
- Tongue
- English
- Weight
- 490 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1420-908X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Ibuprofen is a chiral drug which is used clinically as a racemate. The pharmacological properties of ibuprofen reside almost exclusively with the S( +)-enantiomer. However, a portion of R( -)-ibuprofen is metabolically inverted to its pharmacologically active, mirror-image form. To investigate the i
Stereoselective pharmacokinetics of ibuprofen (IB) enantiomers were studied in rats. Unidirectional conversion from R-ibuprofen (R-IB) to S-ibuprofen (S-IB) was observed following intravenous administration. S-IB concentrations in plasma following racemate administration were simulated according to
The pharmacokinetic parameters of ibuprofen enantiomers after a single 600 mg dose and repeated 3 x 400 mg doses of Nurofen@ were determined in 12 healthy volunteers. Terminal half-lives were similar for both enantiomers, but plasma levels of S-ibuprofen were higher than those of R-ibuprofen, due to
After a single oral dose of (R,S)-ibuprofen (1200 mg) to five healthy volunteers, paired plasma and blister fluid concentrations of drug were determined by a stereospecific HPLC assay. A pharmacokinetic model that incorporated blister fluid as a separate peripheral compartment adequately characteriz