DuP 532, 2-propy1-4-pentafluoroethyl-l-[ [2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylJ imidazole-5-carboxylic acid, is an orally active, non-peptide angiotensin I1 (AII) receptor antagonist. DuP 532 is more potent and longer acting than losartan, another A11 receptor antagonist currently undergoing ph
Pharmacokinetics of SB-247083, a potent and selective endothelinA receptor antagonist, in the rat, dog, and monkey
โ Scribed by Keith W. Ward; Leonard M. Azzarano; Jayme A. Morgan; Michael J. Gould; Cherng-Yih Perng; Pamela R. Souder; David Lundberg; Brian R. Smith
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 119 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.331
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The effect of short term (7 days) and long term (28 days) pretreatment with the imidazole H,-receptor antagonist, cimetidine (CMT), on the pharmacokinetics of 5-fluorouracil (5-FUra) has been studied in the rat and cynomolgus monkey. Short-term pretreatment of rats with CMT significantly increased b
166 is an orally active, non-peptide angiotensin II (AII) receptor antagonist developed for the treatment of hypertension and congestive heart failure (CHF). In this study, the intravenous (iv) and oral (po) single dose pharmacokinetics (PK), oral multiple dose PK and P450-mediated metabolism of 16
Eects of pentobarbital on pharmacokinetics and pharmacodynamics of L-734 217, a potent ยฎbrinogen receptor antagonist, were studied in male dogs. L-734 217 was given intravenously at 0ยด01 mg kg 71 , in a cross-over fashion, to conscious dogs or to dogs anesthetized with pentobarbital. Plasma concentr
## Abstract For Abstract see ChemInform Abstract in Full Text.