Pharmacokinetics of rituximab associated with CHOP chemotherapy in B-cell non-Hodgkin lymphoma
✍ Scribed by Hélène Blasco; Etienne Chatelut; Isabelle Benz De Bretagne; Nicolas Congy-Jolivet; Chantal Le Guellec
- Book ID
- 111194626
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 182 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0767-3981
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## Background The standard treatment for patients with diffuse large-B-cell lymphoma is cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Rituximab, a chimeric monoclonal antibody against the CD20 B-cell antigen, has therapeutic activity in diffuse large-B-cell lymphoma. We conduct
## Abstract Sixty‐six B‐cell lymphoma patients were treated with a CHOP‐based chemotherapy containing rituximab (R‐CHOP‐like regimen). Immune reconstitution was assessed by measuring lymphocyte subsets and immunoglobulins. Fifty‐five patients (83.3%) underwent six cycles of the R‐CHOP‐like regimen.