Pharmacokinetics of orally administered
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M. Van Der Graaff; N. P. E. Vermeulen; P. Heij; J. K. Boeijinga; D. D. Breimer
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Article
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1986
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John Wiley and Sons
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English
β 375 KB
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Hexobarbital (HB) concentrations were determined in plasma and saliva of 8 healthy subjects, following oral administration of 500 mg HB-Na. Mean plasma half-lives were 3.2 k 0.1 h, and salivary half-lives 3.3 k 0.2 h. Mean plasma clearance was 22.9 k 2.3 1 h-'. There was a linear relationship betwee