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PHARMACOKINETICS OF PROPOFOL (DIPRIVAN) IN ELDERLY PATIENTS

โœ Scribed by KIRKPATRICK, T.; COCKSHOTT, I. D.; DOUGLAS, E. J.; NIMMO, W. S.

Book ID
118227569
Publisher
Oxford University Press
Year
1988
Tongue
English
Weight
401 KB
Volume
60
Category
Article
ISSN
0007-0912

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The pharmacokinetics of Chlormezanone (CM) has been determined after a single oral dose of 400 mg CM in 5 young volunteers (28 y) and in 8 elderly patients (79 y). In the young subjects, CM was rapidly absorbed and distributed, and was slowly eliminated with a half-life of 38 h major metabolites wer