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The influence of chronic lobular hepatitis on pharmacokinetics of cefoperazone—a novel galactose single-point method as a measure of residual liver function

✍ Oliver Yoa-Pu Hu; Hung-Shang Tang; Ching-Ling Chang 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 601 KB

Cefoperazone is a semisynthetic cephalosporin antibiotic containing a piperazine side chain, which results in antipseudomonal activity. Unlike the other cephalosporins, it is mainly cleared by the liver (60-8OVo) and it may be more sensitive to changes in the liver function and/or plasma protein bin