PHARMACOKINETICS OF PACLITAXEL ADMINISTERED AS A 3-HOUR OR 96-HOUR INFUSION
โ Scribed by VINODH R.NANNAN PANDAY; WIM W.TEN BOKKEL HUININK; JAN B. VERMORKEN; HILDE ROSING; FRANCISCA J. KOOPMAN; MARTHA SWART; JAN H.M. SCHELLENS; JOS H. BEIJNEN
- Book ID
- 118770680
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 121 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1043-6618
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Tiazofurin, 2-~-D-ribofuranosylthiazole-4-carboxamide, is cytotoxic to murine and human tumor cells. In earlier Phase-1/41 trials performed in other centers in patients with solid tumors, the drug was given mainly as a I O-min bolus or as a continuous i.v. infusion for 5 days. These protocols were a
## Abstract ## BACKGROUND: This study was performed to compare efficacy and toxicity profiles of paclitaxel using 3โhour versus 96โhour infusion schedules. ## METHODS: Patients with metastatic breast cancer (MBC) were randomly assigned to receive paclitaxel starting at a dose of 250 mg/m^2^ intr