✦ LIBER ✦

Pharmacokinetics of oxatomide given percutaneously to healthy volunteers

✍ Scribed by Dr C. Benvenuti; M. Broggini; V. Botta; M. Valenti; G. Broccali; L. Dal Bo

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 321 KB
Volume: 13
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510130703

No coin nor oath required. For personal study only.

✦ Synopsis

The percutaneous absorption of oxatomide gel at 5 per cent concentration was studied after single and repeated administration (85 mg b.i.d.) in six male and six female healthy volunteers, aged 25.750-8 years (mean kSEM) weighing 64-4k4.5 kg and the results compared with those obtained following a single oral dose (30 mg). The measurement of oxatomide was by means of a new sensitive and specific HPLC assay with limits of detection of 0.2ngml-' in plasma and 1.0ngml-' in urine. Poor percutaneous absorption was confirmed by the peak plasma concentrations which were 5.0320.79ngml-' following application of the gel for 7 days and 10.08 f 1 a29 ng ml-* following oral administration; the corresponding amounts of unchanged oxatomide recovered from 24 h urine collections were 1 -42 k 0.39 pg and 3 *93 k 0.92 pg.

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