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Pharmacokinetics of mirodenafil and Its two metabolites, SK3541 and SK3544, in spontaneously or DOCA–salt-induced hypertensive rats

✍ Scribed by Young S. Lee; Young H. Choi; In S. Yoon; Tae K. Kim; Keun H. Ryu; Bong-Y. Lee; Myung G. Lee


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
233 KB
Volume
32
Category
Article
ISSN
0142-2782

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## Abstract The purpose of this study was to investigate the causes for the differences observed in the pharmacokinetics of YJA‐20379‐8 in 16‐week‐old spontaneously hypertensive rats (SHRs). To see if the hereditary characteristics of SHRs was the cause, 20 mg/kg of the drug was intravenously infus