Pharmacokinetics of midazolam in patients recovering from cardiac surgery
โ Scribed by P. O. Maitre; B. Funk; C. Crevoisier; H. R. Ha
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 811 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The pharmacokinetics of midazolam, a water soluble 1,4-benzodiazepine, has been studied in 12 patients (11 male, 1 female; age range 19-57 years) with epilepsy. All patients were taking hepatic enzyme inducing antiepileptic drugs (AEDs) on a regular basis. Midazolam (5 mg) was administered intraveno
The aim of this study was to predict the disposition of midazolam in individual surgical patients by physiologically based pharmacokinetic (PBPK) modeling and explore the causes of interindividual variability. Tissueยฑplasma partition coefยฎcients (k p ) were scaled from rat to human values by a physi