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Pharmacokinetics of midazolam in critically ill neonates

โœ Scribed by E. Jacqz-Aigrain; C. Wood; I. Robieux

Publisher
Springer
Year
1990
Tongue
English
Weight
224 KB
Volume
39
Category
Article
ISSN
0031-6970

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โœฆ Synopsis

Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children. An IV bolus of midazolam 0.2 mg.kg-1 was administered to 10 critically ill neonates receiving intensive care who required sedation. The plasma clearance was 6.85 ml.min-1 and the elimination half-life was 6.52 h. Midazolam was well tolerated during and after administration. Because of its short half-life compared to diazepam, midazolam could be used during the neonatal period to produce brief rapid sedation.

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