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Pharmacokinetics of midazolam and its main metabolite 1-hydroxymidazolam in intensive care patients

✍ Scribed by R. Boulieu; B. Lehmann; F. Salord; C. Fisher; D. Morlet


Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
491 KB
Volume
23
Category
Article
ISSN
0378-7966

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A simple, selective high-performance liquid chromatographic method with ultraviolet detection at 220 nm is described for quantitation of midazolam and its primary metabolite 1-hydroxymidazolam in 100 pL plasma samples from premature infants. A mobile phase of acetonitrile: tetrahydr0furan:phosphate