✦ LIBER ✦

Pharmacokinetics of maprotiline and its demethylated metabolite in serum and specific brain regions of rats after acute and chronic administration of maprotiline

✍ Scribed by Katsushi Miyake; Hiroshi Fukuchi; Teruaki Kitaura; Masahiko Kimura; Yasuhiro Kimura; Toshio Nakahara

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 542 KB
Volume: 80
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600801205

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pharmacokinetic analysis of maprotiline

Pharmacokinetic analysis of maprotiline and its demethylated metabolite in serum and brain of rats after acute and chronic oral administration of maprotiline

✍ Katsushi Miyake; Hiroshi Fukuchi; Teruaki Kitaura; Masahiko Kimura; Yasuhiro Kim 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 639 KB

Pharmacokinetics of amitriptyline and it

Pharmacokinetics of amitriptyline and its demethylated metabolite in serum and specific brain regions of rats after acute and chronic administration of amitriptyline

✍ Katsushi Miyake; Hiroshi Fukuchi; Teruaki Kitaura; Masahiko Kimura; Keisuke Sara 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB

Pharmacokinetics of desethylamiodarone i

Pharmacokinetics of desethylamiodarone in the rat after its administration as the preformed metabolite, and after administration of amiodarone

✍ Anooshirvan Shayeganpour; Dalia A. Hamdy; Dion R. Brocks 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views

## Abstract The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone (AM), were studied in the rat after administration of AM or preformed metabolite. Rats received 10 mg/kg of either intravenous or oral AM HCl or DEA base. Blood samples were obtained via a surgically i

Regional distribution of diazepam and it

Regional distribution of diazepam and its metabolites in the brain of cat after chronic treatment

✍ G. F. Placidi; G. Tognoni; G. M. Pacifici; G. B. Cassano; P. L. Morselli 📂 Article 📅 1976 🏛 Springer 🌐 English ⚖ 453 KB

Repeated administration of diazepam leads to remarkable accumulation of N-desmethyldiazepam in white matter structures and in subcortical areas such as thalamus, hypothalamus, and hypophysis. Diazepam and the hydroxylated metabolites were present in lesser amounts. The distribution pattern of diazep

Simultaneous measurement of biogenic ami

Simultaneous measurement of biogenic amines and their metabolites in rat brain regions after acute administration of and abrupt withdrawal from butorphanol or morphine

✍ Hiroyuki Wakabayashi; Shogo Tokuyama; Ing K. Ho 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 707 KB

Comparison of pharmacokinetics of loxopr

Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: Evidence for extrahepatic metabolism

✍ Tae-Sung Koo; Dae-Hyun Kim; Sung-Hoon Ahn; Kang-Pil Kim; In-Wha Kim; Seung-Yong 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

The objective of this study was to characterize the extent of the formation of the active (trans-alcohol form) and inactive (cis-alcohol) metabolites of loxoprofen and to compare the kinetics after its intragastric, intravenous, and intramuscular administrations in rats. After intravenous administra