Pharmacokinetics of ketoprofen in the elderly.
β Scribed by C Advenier; A Roux; C Gobert; P Massias; O Varoquaux; B Flouvat
- Book ID
- 117943193
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 678 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0306-5251
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π SIMILAR VOLUMES
## Abstract The pharmacokinetic profile of ketoprofen suppositories following single and chronic (32 doses) administration to 12 healthy adult male volunteers was established. Each subject received a single rectal dose of 100 mg of ketoprofen on day 1, followed by one suppository of 100 mg b.i.d. f
Ketoprofen (KT), a chiral nonsteroidal anti-inflammatory drug (NSAID), is marketed and used as a racemic mixture. In healthy volunteers, negligible differences have been reported between the plasma time courses of KT enantiomers. Using a stereospecific high-performance liquid chromatographic (HPLC)