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Pharmacokinetics of ketoprofen in rabbit after a single topical application

โœ Scribed by C. Audeval-Gerard; C. Nivet; A -I. K. El Amrani; P. Champeroux; J. Fowler; S. Richard


Book ID
105732177
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
515 KB
Volume
25
Category
Article
ISSN
0378-7966

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Deacetyl diltiazem (M 1 ) is a major metabolite of the widely used calcium antagonist diltiazem (DTZ). In order to study the pharmacokinetic and haemodynamic effects of this metabolite, M 1 was administered as a single 5 mg kg -1 dose intravenously (iv) to New Zealand white rabbits (n = 5) via a mar