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Pharmacokinetics of isosorbide dinitrate in rhesus monkey, cynomolgus monkey, and baboon

✍ Scribed by E. Doyle; L. F. Chasseaud

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 385 KB
Volume: 70
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600701122

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## Abstract Plasma concentrations of isosorbide dinitrate have been measured after intravenous infusion of drug at a rate of 5·0 mg h^−1^ for 150 min and after single equal oral doses of 12·5 mg of drug in solution to two normal human subjects. During the infusion, uneven plateau concentrations wer