Pharmacokinetics of intravenous methotrexate in mutant Nagase analbuminemic rats
โ Scribed by Young H. Choi; Soo K. Bae; Jung M. Oh; Sun-Ok Kim; Myung G. Lee
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 127 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.565
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Pharmacokinetic parameters of oltipraz were compared after intravenous (10 mg/kg) and oral (50 mg/kg) administration to control male Sprague-Dawely rats and mutant Nagase analbuminemic rats (NARs). In NARs, the expression and mRNA level of CYP1A2 increased, and oltipraz was mainly metabolized via CY
## Abstract It has been reported that plasma albumin concentrations were significantly lower in cancer patients than those in the healthy volunteers, and the expression and mRNA level of hepatic microsomal cytochrome P450 (CYP) 1A2 increased in mutant Nagase analbuminemic rats (NARs). After intrave