Pharmacokinetics of Intravenous Fenvalerate in Cattle Treated Topically with a Low Dose of Piperonyl Butoxide
✍ Scribed by Danielson, Terry J.; Golsteyn, Lorraine R.; Elder, James L.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 209 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1526-498X
No coin nor oath required. For personal study only.
✦ Synopsis
Experiments were conducted to identify pharmacokinetic interactions between topically applied piperonyl butoxide and intravenous fenvalerate in cattle (Angus steers). Intact fenvalerate in plasma was derivatized by condensation with acetone and measured by negative chemical ionization gas chromatography/mass spectrometry. Noncompartmental pharmacokinetic analyses indicated that the elimination-phase rate constant (b, 0É000 69 (^0É000 06) min~1), mean residence time (172 (^14) min), systemic clearance (10É4 (^0É7) ml min~1 kg~1) or volume at steady state (1800 (^230) ml kg~1) were not changed (P [ 0É05) after topical application of a low dose of piperonyl butoxide. These data indicate that topical application of a low dose of the metabolic synergist piperonyl butoxide would not be expected to modify the in-vivo disposition of fenvalerate in cattle.