Pharmacokinetics of high-dose methotrexate treatment in children
β Scribed by D. Bratlid; P. J. Moe
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 384 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND Highβdose methotrexate (HDMTX) is used frequently in combination regimens that include nephrotoxic chemotherapy. The authors evaluated the impact of factors such as age and prior nephrotoxic agents on MTX pharmacokinetics in children and young adults with osteosarcoma and
A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtaine