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Pharmacokinetics of granisetron in rat blood and brain by microdialysis

✍ Scribed by Chien-Tsai Huang; Chieh-Fu Chen; Tung-Hu Tsai

Book ID
117176220
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
826 KB
Volume
64
Category
Article
ISSN
0024-3205

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The purpose of this study was to investigate the effect of dose on norfloxacin pharmacokinetics and distribution into the brain extracellular fluid (ECF), in freely moving rats. Unbound concentrations of norfloxacin in hippocampus were determined by microdialysis after an i.v. bolus dose of 12.5, 25