✦ LIBER ✦

Pharmacokinetics of flurbiprofen in man. I. Area/dose relationships

✍ Scribed by G. J. Szpunar; K. S. Albert; G. G. Bole; J. N. Dreyfus; G. F. Lockwood; Dr J. G. Wagner

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 507 KB
Volume: 8
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510080308

No coin nor oath required. For personal study only.

✦ Synopsis

Flurbiprofen pharmacokinetics were studied in 15 normal male subjects after four oral doses. Plasma levels of total (bound + free) drug were monitored for 48 h and urine was collected for 96 h after the doses. All subjects demonstrated linear relationships between administered dose and total flurbiprofen AUC, indicating that oral clearance is independent of dose for the dose range evaluated in this study. Urinary recovery data indicated that the efficacy of absorption was dose independent.

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