Pharmacokinetics of fluconazole after oral administration in children with human immunodeficiency virus infection

✍ Scribed by M. C. Nahata; M. T. Brady

• Publisher: Springer
• Year: 1995
• Tongue: English
• Weight: 264 KB
• Volume: 48-48
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00198314

✦ Synopsis

The objective of this study was to determine the pharmacokinetics of fluconazole after oral administration in children with human immunodeficiency virus (HIV) infection. After an overnight fast, a single dose of either 2 rag" kg-1 or 8 mg kg-1 was administered in a suspension; five children received 2 mg'kg 1 and four 8 mg'kg -1 (ages 5-13 years). Blood samples were collected at various times on day 1, and once daily on days 2-7 after the dose. Fluconazole serum concentrations were measured by gas chromatography. At the dose of 2 mg'kg -1, the Cmax, AUC (0-oo), and tl/2 ranged from 2.3-4.4 btg'm1-1, 84.9-136 gg.h'm1-1, and 19.8 34.8 h, respectively. At the dose of 8 mg'kg 1 the Cmax, AUC (0-~), and tl/2 ranged from 5.4-12.1 btg ml-1,330-684 gg h' ml -1, and 25.6-42.3 h, respectively. When compared with published data in healthy adults, fluconazole achieved similar serum concentrations in the present group of children, indicating a nearly complete degree of absorption.