The effects of pretreatment with symmetrically dihalogenated biphenyls (DXBs, X-F, Cl(C), Br(B) and I) on rat liver drug metabolism enzymes were investigated. 4,4'-DFB, -DCB, and -DBB as well as 2,2'-DFB appeared to be inducers of microsomal cytochrome P-450-linked monoxygenases (N-demethylases of a
โฆ LIBER โฆ
Pharmacokinetics of drugs that inactivate metabolic enzymes
โ Scribed by Murray R. Gray; Yun K. Tam
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 692 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0022-3549
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The objective of this study was to characterize the clinical pharmacokinetic profile of lofexidine after oral delivery. A single dose, cross-over study and a multidose study using healthy volunteers were conducted for that purpose. In the single dose study the average time to maximum concentration w