𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetics of droloxifen compared to tamoxifen

✍ Scribed by Breitbach, GP; Reister, C; Bastert, G

Book ID
122042515
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
153 KB
Volume
29
Category
Article
ISSN
0959-8049

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

No loss of estrogenic or anti-estrogenic
No loss of estrogenic or anti-estrogenic activity after demethylation of droloxifene (3-OH-Tamoxifen)
✍ R. LΓΆser; K. Seibel; U. Eppenberger πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 French βš– 254 KB

The bindin affinity of 3-OH-Tamoxifen (Droloxifene or DR8L) and N-demethyl-droloxifene (ND-DROL) to the cystosolic estrogen receptor of rabbit uteri was 10 times higher than that of Tamoxifen. Both compounds exhibited similar stimulation (estrogenic effect) and inhibition (anti-estrogenic effect) of

Pharmacokinetics of tamoxifen after intr
Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifen–hydroxybutenyl-Ξ²-cyclodextrin formulations
✍ Buchanan, Charles M. (author);Buchanan, Norma L. (author);Edgar, Kevin J. (autho πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons Inc. 🌐 English βš– 364 KB

Oral and intravenous administration of tamoxifen base and tamoxifen citrate formulated with hydroxybutenyl-beta-cyclodextrin (HBenBCD) to Sprague-Dawley rats significantly increased the oral bioavailability of tamoxifen relative to that of parent drug (no HBenBCD). When formulated with HBenBCD, the