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Pharmacokinetics of Diltiazem and its major metabolite, Deacetyldiltiazem after oral administration of Diltiazem in mild and medium folate-induced renal failure rabbits

✍ Scribed by Jun Shik Choi; Jin Hwan Lee; Jin Pil Burm

Publisher
Springer
Year
2001
Tongue
English
Weight
380 KB
Volume
24
Category
Article
ISSN
0253-6269

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The pharmacokinetics of oral diltiazem were studied in 10 patients with chronic renal failure not requiring dialysis and in five healthy volunteers after a single dose of 120mg. We found that patients with chronic renal failure had lower amounts of unchanged diltiazem and of its main metabolite (MA)