Pharmacokinetics of dexamethasone and its phosphate ester

✍ Scribed by Peter Rohdewald; Helmut Möllmann; Jürgen Barth; Jörg Rehder; Dr. Hartmut Derendorf

• Book ID: 101702187
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 358 KB
• Volume: 8
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510080302

✦ Synopsis

Dexamethasone in form of its phosphate was given intravenously in two different doses (1.5mg kg-' and 15mg). Plasma levels of the ester and dexarnethasone were measured and pharmacokinetic parameters were calculated. The results indicate no dose-dependency of the pharmacokinetic parameters in the investigated range for dexamethasone. Conversion from the prodrug to the active form was rapid; maximum dexamethasone plasma concentrations were reached after 10 min. The results were verified by dexamethasone level monitoring in patients after chronic dosing. Predicted and achieved steady state levels agreed well.