Pharmacokinetics of amoxicillin coadministered with a saline-polyethylene glycol solution in healthy volunteers

✍ Scribed by C. Padoin; Dr. M. Tod; N. Brion; K. Louchahi; V. Le Gros; O. Petitjean

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 396 KB
• Volume: 16
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510160302

✦ Synopsis

The pharmacokinetics of orally administered amoxicillin were investigated in 12 healthy volunteers in a crossover design. They received either a placebo or a saline-polyethylene glycol solution (SPG) for 4 d, the last dose being given simultaneously with 1 g amoxicillin; blood samples were drawn for the next 12 h. Amoxicillin kinetics were similar in the two treatments but small differences in some pharmacokinetic parameters reached significance. The mean + SD area under the curve was lower with SPG (43.8 L-6-8 against 4 7 -8 + 8 -2 mg h L-', p<0-05) but the treatments were equivalent according t o Westlake's test (95% confidence interval = 14.95%). Analysis of SPG against placebo amoxicillin absorption kinetics after fitting the data to a Weibull model revealed a longer duration of the absorption, a slower rate of absorption, and a different shape of the curve. No clinical consequences are expected from these minor variations but possible mechanisms could be relevant to other drugs.