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Pharmacokinetics of aditoprim, a dihydrofolate reductase inhibitor, in sheep

✍ Scribed by K. HAENNI; J.-C JORDAN; B. LUDWIG; W. F. REHM

Book ID
114744458
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
162 KB
Volume
10
Category
Article
ISSN
0140-7783

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## Abstract A simple, highly sensitive radioassay was developed for the activity of a newly discovered inhibitor of dihydrofolate reductase (DHFR), aditoprim. The procedure is based on the inhibition of binding of [^3^H]‐methotrexate ([^3^H]MTX) with bacterial dihydrofolate reductase by the antifol