Pharmacokinetics of a new antitumor 3-arylisoquinoline derivative, CWJ-a-5
โ Scribed by Ki-Eun Kim; Won-Jea Cho; Soon-Jae Chang; Chul-Soon Yong; Chi-Ho Lee; Dae-Duk Kim
- Book ID
- 108453961
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 135 KB
- Volume
- 217
- Category
- Article
- ISSN
- 0378-5173
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BMY-28175 is a novel antitumor antibiotic produced in fermentation by Actinomadura verrucosospora. The cytotoxic effects of BMY-28175 were determined using murine and human tumor cell lines in vitro. Following 72 hour exposure, the drug had IC50 values 1.5 to 13.5 ng/ml in a microtiter assay. BMY-28