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Pharmacokinetics, Metabolism, and in Vivo Efficacy of the Antimalarial Natural Product Bromophycolide A

✍ Scribed by Teasdale, Margaret E.; Prudhomme, Jacques; Torres, Manuel; Braley, Matthew; Cervantes, Serena; Bhatia, Shanti C.; La Clair, James J.; Le Roch, Karine; Kubanek, Julia

Book ID
120979498
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
418 KB
Volume
4
Category
Article
ISSN
1948-5875

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## Abstract __Hypothemycin and related resorcylic acid lactones (RAL) bearing a__ cis__‐enone moiety have emerged as an alternative pharmacophore to heterocyclic motifs for kinase inhibition, and are endowed with a unique selectivity filter based on the irreversible reaction with a subset of the ki