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Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

✍ Scribed by Baumann, Andreas; Tuerck, Dietrich; Prabhu, Saileta; Dickmann, Leslie; Sims, Jennifer


Book ID
127113185
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
532 KB
Volume
19
Category
Article
ISSN
1359-6446

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The growing use of local drug delivery to vascular tissues has increased interest in hydrophobic compounds. The binding of these drugs to serum proteins raises their levels in solution, but hinders their distribution through tissues. Inside the arterial interstitium, viscous and steric forces and bi