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Pharmacokinetics, antifolate activity and tissue distribution of PT523 in SCC VII tumor-bearing mice

✍ Scribed by Joel E. Wright; Mario Pardo; Anatoly Tretyakov; Wendy L. Alperin; Dorothy Trites; Andre Rosowsky

Publisher: Springer
Year: 1998
Tongue: English
Weight: 243 KB
Volume: 42
Category: Article
ISSN: 0344-5704
DOI: 10.1007/s002800050821

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## Abstract The distribution of Photofrin II (P‐II) and aluminum phthalocyanine tetrasulfonate (AIPCS~4~) in tissues of BALB/c nu/nu nude mice bearing the LOX human melanoma was measured fluorimetrically at different times after intraperitoneal injection of the drugs, 20 mg/kg body weight. The plas