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Pharmacokinetics and toxicity of idarubicin in the rat

✍ Scribed by Olaf Kuhlmann; Stefan Hofmann; Michael Weiss


Book ID
105737288
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
672 KB
Volume
26
Category
Article
ISSN
0378-7966

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## Abstract We have studied the pharmacokinetics of idarubicin and daunorubicin in a total of 16 leukemic patients treated with one of these drugs associated with aracytine. The AUCs obtained for unchanged drugs were proportional to the dose, and the dose‐independent pharmacokinetic parameters were

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Idarubicin-loaded solid lipid nanoparticles (IDA-SLN) and idarubicin in solution were prepared and the two formulations were administered to rats, either by the duodenal route or intravenously (iv). The aim of this research was to study whether the bioavailability of idarubicin can be improved by ad