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Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co-administered in healthy female subjects

โœ Scribed by Emma Andrews; Bharat D. Damle; Annie Fang; Grover Foster; Penelope Crownover; Robert LaBadie; Paul Glue


Book ID
108642017
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
721 KB
Volume
65
Category
Article
ISSN
0306-5251

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Hexobarbital (HB) concentrations were determined in plasma and saliva of 8 healthy subjects, following oral administration of 500 mg HB-Na. Mean plasma half-lives were 3.2 k 0.1 h, and salivary half-lives 3.3 k 0.2 h. Mean plasma clearance was 22.9 k 2.3 1 h-'. There was a linear relationship betwee