Pharmacokinetics and tissue disposition of danofloxacin in sheep

✍ Scribed by Quintin A. McKellar; Ian F. Gibson; Robert Z. McCormack

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 172 KB
• Volume: 19
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/(sici)1099-081x(199803)19:2<123::aid-bdd89>3.0.co;2-g

✦ Synopsis

The plasma pharmacokinetics of danofloxacin administered at 1.25 mg kg -1 body weight by the intravenous and intramuscular routes were determined in sheep. Tissue distribution was also determined following administration by the intramuscular route at 1.25 mg kg -1 body weight. Danofloxacin had a large volume of distribution at steady state (V d ss ) of 2.76 90.16 h (mean 9S.E.M.) L kg -1 , an elimination half-life (t 1/2i ) of 3.359 0.23 h, and a body clearance (C1) of 0.63 90.04 L kg -1 h -1 . Following intramuscular administration it achieved a maximum concentration (C max ) of 0.32 90.02 mg mL -1 at 1.2390.34 h (t max ) and had a mean residence time (MRT) of 5.4590.19 h. Danofloxacin had an absolute bioavailability (F) of 95.71 94.41% and a mean absorption time (MAT) of 0.81 9 0.20 h following intramuscular administration. Mean plasma concentrations of \0.06 mg mL -1 were maintained for more than 8 h following intravenous and intramuscular administration. Following intramuscular administration highest concentrations were measured in plasma (0.43 9 0.04 mg mL -1 ), lung (1.51 90.18 mg g -1 ), and interdigital skin (0.6490.18 mg g -1 ) at 1 h, duodenal contents (0.819 0.40 mg mL -1 ), lymph nodes (4.619 0.35 mg g -1 ), and brain (0.0690.00 mg mL -1 ) at 2 h, jejunal (10.509 4.31 mg mL -1 ) and ileal (5.25 91.67 mg mL -1 ) contents at 4 h, and colonic contents (8.949 0.65 mg mL -1 ) at 8 h.