Pharmacokinetics and sedative effects in healthy subjects and subjects with impaired liver function after continuous infusion of clomethiazole
✍ Scribed by Carina Centerholt; Marianne Ekblom; Tomas Odergren; Olof Borgå; Gabriela Popescu; Karl-Heinz Molz; Andrea Couturier; Angelika Weil
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 226 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0031-6970
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The steady-state pharmacokinetics of nefazodone (NEF) and its metabolites hydroxynefazodone (HO-NEF) and m-chlorophenylpiperazine (mCPP) were compared in subjects with normal and impaired renal function. Patients: The Study was of parallel group design which included 7 subjects with normal (NOR) ren
The single-dose pharmacokinetics of nefazodone (NEF) and its metabolites hydroxynefazodone (HO-NEF) and m-chlorophenylpiperazine (mCPP) were examined in 12 healthy younger subjects < 55 years of age (YNG), 12 elderly subjects > 65 years of age (ELD), 12 patients with biopsy proven hepatic cirrhosis