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Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes

✍ Scribed by Mia Hedman; Marjatta Antikainen; Christer Holmberg; Mikko Neuvonen; Michel Eichelbaum; Kari T. Kivistö; Pertti J. Neuvonen; Mikko Niemi


Book ID
108641588
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
177 KB
Volume
61
Category
Article
ISSN
0306-5251

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The aim of this study was to investigate whether the heterogeneity in tacrolimus dose requirement is associated with ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients during the first month after transplantation. ABCB1 and CYP3A5 genotyping was performed using the polymerase c