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Pharmacokinetics and pharmacodynamics of protein-unbound docetaxel in cancer patients

✍ Scribed by Hironobu Minami; Kenji Kawada; Yasutsuna Sasaki; Tadahiko Igarashi; Toshiaki Saeki; Makoto Tahara; Kuniaki Itoh; Hirofumi Fujii

Book ID
108583607
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
112 KB
Volume
97
Category
Article
ISSN
1347-9032

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Significance of protein binding in pharm
Significance of protein binding in pharmacokinetics and pharmacodynamics
✍ Stephan Schmidt; Daniel Gonzalez; Hartmut Derendorf πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 243 KB

The significance of plasma protein binding on drug efficacy and, subsequently, the clinical relevance of changes in protein binding has been controversially discussed for decades. The uncertainty concerning the impact of plasma protein binding on a drug's pharmacological activity is, in part, relate