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Pharmacokinetics and pharmacodynamics of physostigmine after intravenous administration in beagle dogs

✍ Scribed by E. Giacobini; S. Somani; M. McIlhany; M. Downen; M. Hallak


Book ID
118955663
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
666 KB
Volume
26
Category
Article
ISSN
0028-3908

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✍ Satu M. Somani πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 789 KB

The distribution, metabolism, and pharmacokinetics of physostigmine (Phy) and the time course of butyrylcholinesterase (BuChE) in plasma and cholinesterase (ChE) activity in brain and muscle and their relationship to Phy concentration were described after oral administration of 3H-Phy (650pg kg-') t