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Pharmacokinetics and Pharmacodynamics of Liraglutide, a Long-Acting, Potent Glucagon-Like Peptide-1 Analog

โœ Scribed by Jerry Meece


Book ID
115049953
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
109 KB
Volume
29
Category
Article
ISSN
0277-0008

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Pharmacokinetic and pharmacodynamic eval
โœ Su Young Chae; Young Goo Chun; Seulki Lee; Cheng-Hao Jin; Eun Seong Lee; Kang Ch ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 337 KB

The rapid elimination of glucagon-like peptide-1 (GLP-1) is the main impediment to its anti-diabetic utility. Here, we tried to improve its poor pharmacokinetic/pharmacodynamic profiles using PEGylation. The site-specific (Lys 34 ) PEGylated GLP-1s were synthesized with PEGs of 2, 5, and 10 kDa, res