A convenient synthesis of 13C4-Leflunomi
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Robert J. Faragher; John. M. Motto; Maciej A. Kaminski; Adrian L. Schwan
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Article
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2003
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John Wiley and Sons
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French
β 113 KB
## Abstract A convenient synthesis of leflunomide and its primary pharmacologically active metabolite A77 1726, each labeled with four ^13^C atoms has been achieved. Starting from ^13^C~4~βethyl acetoacetate, each step of the synthesis proceeds in 60β82% yield. Analysis of the mass spectra of the l