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Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

✍ Scribed by Noriaki Kurata; Takashi Kuwabara; Hiromi Tanii; Eiichi Fuse; Tadakazu Akiyama; Shiro Akinaga; Hiroyuki Kobayashi; Ken Yamaguchi; Satoshi Kobayashi

Book ID
105994498
Publisher
Springer
Year
1999
Tongue
English
Weight
121 KB
Volume
44
Category
Article
ISSN
0344-5704

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Time to disease progression to evaluate
Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma
✍ Brian I. Rini; Vivian Weinberg; Vanessa Shaw; Janet Scott; Robert Bok; John W. P πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 80 KB

## Abstract ## BACKGROUND Renal cell carcinoma (RCC) is characterized by von Hippel‐Lindau gene inactivation and vascular endothelial growth factor (VEGF) overproduction. The mechanism of VEGF overproduction may involve protein kinase C (PKC) delta and zeta isoforms. UCN‐01 (7‐hydroxystaurosporine