The pharmacokinetics and pharmacodynamic
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P. Lundborg; B. Abrahamsson; I. Wieselgren; M. Walter
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Article
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1993
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Springer
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English
โ 302 KB
We have studied a controlled-release formulation containing metoprolol 100 mg and hydrochlorothiazide 12.5 mg. We compared the pharmacokinetics of both substances and the pharmacodynamics of metoprolol with those of a conventional combination tablet. The controlled-release formulation gave less vari