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Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine

✍ Scribed by G. Mikus; H. R. Ha; S. Vožeh; C. Zekorn; F. Follath; M. Eichelbaum

Publisher: Springer
Year: 1986
Tongue: English
Weight: 269 KB
Volume: 31
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00870989

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## Abstract Metoprolol is a β‐blocker and its racemic mixture is used for the treatment of hypertension. In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats. Male Wistar rats (__n__ = 6 per group) received racemic metoprolol