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Pharmacokinetics and metabolism of ethylenediamine in the Swiss Webster mouse following oral or intravenous dosing

✍ Scribed by Hon-Wing Leung


Book ID
119536905
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
85 KB
Volume
117
Category
Article
ISSN
0378-4274

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The metabolism and disposition of diethylenetriamine trihydrochloride (DETAβ€’3HCl) were studied with regard to route of administration and dosage effects. Male Fischer 344 rats were administered 50 or 500 mg kg -1 of [1,2-14 C]-DETAβ€’3HCl orally or endotracheally, and the fate of the 14 C-radioactivit