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Pharmacokinetics and haemodynamic effects of a single oral dose of the novel ACE inhibitor spirapril in patients with chronic liver disease

✍ Scribed by S. Krähenbühl; P. Grass; A. Surve; K. Kutz; J. Reichen


Publisher
Springer
Year
1993
Tongue
English
Weight
637 KB
Volume
45
Category
Article
ISSN
0031-6970

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In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari