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Pharmacokinetics and Haemodynamic Effect of Diltiazem in Rats: Effect of Route of Administration

โœ Scribed by BAN C. H. TSUI; JOE D. Z. FENG; POLLEN K. F. YEUNG

Book ID
118111192
Publisher
Pharmaceutical Press
Year
1998
Tongue
English
Weight
510 KB
Volume
50
Category
Article
ISSN
2042-7158

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Pharmacokinetics and haemodynamic effect
Pharmacokinetics and haemodynamic effect of deacetyl diltiazem (M1) in rabbits after a single intravenous administration
โœ Pollen K. F. Yeung; Joe D. Z. Feng; Susan J. Buckley ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 147 KB ๐Ÿ‘ 2 views

Deacetyl diltiazem (M 1 ) is a major metabolite of the widely used calcium antagonist diltiazem (DTZ). In order to study the pharmacokinetic and haemodynamic effects of this metabolite, M 1 was administered as a single 5 mg kg -1 dose intravenously (iv) to New Zealand white rabbits (n = 5) via a mar